Juve forward Cristiano Ronaldo had an unusually quiet game after scoring a hat-trick against Atletico in last year's competition, although he came within inches of grabbing a last-gasp winner when he sent a shot just past the far post.
Chelsea have the upper hand ahead of next week's Champions League semi-final, second leg after holding Atletico Madrid to a frustrating 0-0 draw in Tuesday's first leg.
Bayer Leverkusen beat Freiburg 3-2 to edge closer to a first ever Bundesliga title.
Manchester City came out on top in an epic Champions League battle against Monaco whereasAtletico Madrid beat hosts Bayer Leverkusen 4-2 in a topsy-turvy encounter.
Their limp performance does not inspire confidence ahead of the visit of the all-powerful Serie A leaders and familiar foe Cristiano Ronaldo.
Spain face Ronald Koeman's Netherlands away on Thursday before returning home for the second-leg on March 23.
The Catalonian side put up a good fight to stay level in the first half at a half-empty Wanda Metropolitano stadium, with Lucas Hernandez hitting the post and Diego Costa denied when one-on-one with the visiting keeper.
Barcelona, Atletico Madrid and Real Madrid resume a nail-biting La Liga title race on Saturday after all notched up victories on Wednesday. Leaders Barcelona, who ended a four-game winless streak by hammering Deportivo La Coruna 8-0 away from home, host struggling Sporting Gijon on Saturday. Atletico battled to a 1-0 win at Athletic Bilbao to stay level on 79 points with Barcelona, who top the table with a superior head-to-head record and host Malaga. Real stayed one point behind their title rivals after beating Villarreal 3-0 and are expected to be without top scorer Cristiano Ronaldo for their visit to struggling neighbours Rayo Vallecano. The Portuguese forward was unable to finish the game against Villarreal after suffering cramp in stoppage time but eased concerns he had suffered a serious injury.
Atletico Madrid celebrated like they had won the trophy after reaching the Champions League quarter-finals by edging past PSV Eindhoven 8-7 on penalties on Tuesday following 210 goalless minutes in their last-16 tie.
Watford knocked out of FA Cup; third-tier side Cultural Leonesa shock Madrid team.
Holders Real Madrid will need to maintain their intensity for the whole of next week's return leg if they are to get past Atletico Madrid into the Champions League semi-finals, coach Carlo Ancelotti said on Tuesday.
Real's victory at the Santiago Bernabeu means they are poised to knock Atletico out of the competition for the fourth successive year.
Atletico Madrid coach Diego Simeone is renowned for his wild touchline antics but a shrewd tactical move with a triple substitution swung Wednesday's Champions League game against Juventus firmly his side's way.
'At no time did I, nor was it my intention, infringe upon the intimacy of my fellow professional Daniela Caracas.'
Before Leicester enchanted the sporting world last year with their miraculous Premier League title win, Atletico had worked similar wonders in 2014 by breaking the strangehold of Real Madrid and Barcelona in La Liga.
Atletico Madrid will have centre backs Diego Godin and Stefan Savic available again for Tuesday's Champions League quarter-final first leg at Barcelona.
Atletico Madrid crashed out of the Copa del Rey to Girona on Wednesday following a highly entertaining 3-3 draw at home to the Catalan side, who sneaked through to the quarter-finals on away goals after the tie finished 4-4 on aggregate.
If Atletico Madrid win a first Champions League title by beating city rivals Real Madrid on Saturday they will become the most successful team in the club's history, eclipsing the La Liga and King's Cup double winners of 1996.
The Brazilian scored twice in a 3-0 victory over Atletico Madrid that sent Real Madrid to the top of the Primera Liga.
A summary of Saturday's action in the LaLiga, Serie A and Bundesliga.
Diego Simeone has opened the door to the possibility of leaving Atletico Madrid in the next two years after announcing on Friday that he had reduced his contractual commitment from 2020 to 2018.
Atletico Madrid's Luis Suarez struck two late goals to give the LaLiga champions a 2-1 win at Getafe on Tuesday after the hosts were reduced to 10 men late in the second half.
Atletico Madrid cruised to a 3-0 home win over Real Sociedad on Tuesday to close the gap behind La Liga leaders Barcelona to five points.
Chelsea outplay Villa in FA Cup
A round-up of Saturday's football action in La Liga, Bundesliga and Ligue 1.
Real Madrid win UEFA Champions League
Antoine Griezmann and Samuel Lino scored in each half to give Atletico Madrid a 2-0 win over Lazio on Wednesday that secured them top spot in Champions League Group E, the first time since 2016 that they had reached the knockouts as group winners.
IMAGES from the UEFA Champions League matches played on Wednesday.
Ernesto Valverde's Bilbao team punished the visitors with clinical counter-attacks, playing with the advantage of having won the first leg 1-0 in Madrid.
IMAGES from football matches played across Europe on Wednesday.
Real Madrid, Barcelona and Atletico Madrid, find themselves in the bizarre situation of having made poor starts to the campaign
First meets second as Barcelona host Atletico Madrid on Saturday looking to tighten their grip on the La Liga title race. The sides are level on 48 points at the top of the table, but Barca have a game in hand on Atletico and can take a huge step towards a fifth title in seven years with an eighth consecutive win in all competitions. Indeed, Luis Enrique's men remain on course for a repeat of the treble of La Liga, Champions League and Copa del Rey they won last season after progressing to the semi-finals of the Cup with a come from behind 3-1 win over Athletic Bilbao in midweek. Yet, the European champions have been far from their best in the past week as they were outplayed by Malaga and Bilbao in the first-half before being salvaged by individual moments of magic after the break. "We are aware of the errors we need to correct," said Luis Suarez after taking his tally for the season already to 30 with the equalizer against Bilbao.
Barcelona trounced visitors Atletico Madrid 6-1 at the Nou Camp on Saturday to move into second place behind Villarreal in the Primera Liga. Villarreal have 16 points from six games after coming from behind to beat Real Betis 2-1 while Barca are on 13 after a scoring spree led by a double from Samuel Eto'o.
Cristiano Ronaldo was singled out by Atletico Madrid fans on Wednesday as Juventus lost 2-0 in the Champions League last 16 but the former Real Madrid forward was quick to point out his stellar record in the competition.
Girona thrash Osasuna for first win of the season
UEFA to not place sanctions on PSG
Tottenham Hotspur defender Toby Alderweireld insists his run to the Champions League final with Atletico Madrid two years ago proves that underdogs can compete with Europe's elite and win the competition.
Diego Costa gave Europa League holders Atletico a dream start against Champions League winners Real by firing them ahead after 49 seconds, knocking down a long pass and smashing the ball into the net from a tight angle.
A first-half penalty earned Lille a shock 1-0 home victory over holders Real Madrid in the Champions League group phase on Wednesday.
